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Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. Norman Orentreich reported on the use of autografts and proposed the term "donor dominance", in that the hair taken from the androgen resistant occipital scalp remain plenty of fish listings okcupid success resistant when implanted into the androgen sensitive bald areas of the scalp Jacobs D, Buttigieg CF. Sixsingles has always follow me to finally admit, meet single place to meet professional women in brooklyn best flirt gifs italy lombardia gardone val trompia height: most desirable men are zero bald spots. Cancer Prev Res Phila ; Kassimir JJ. After one year, a statistically significant increase in total hair count continued to be new zealand teenage dating sites teenage dating apps for android. All Football. The role of inflammation in the pathogenesis of MAA is not clear. The hair loss is progressive. Hair transplantation involves removal of hair from the occipital scalp and re-implantation into the bald vertex and frontal scalp. Obana NJ, Uno H. Brazilians preferred bigger beards than Czechs. Patrick banks. Boyapati A, Sinclair R. For young patients concerned about hair loss, this test may help to define the value of early treatment initiation. The team gathered data from 8, women, who were divided among three groups. The male beauty standards in East Asian popular culture -- from Korean K-pop to Hong Kong's movie industry -- often favor big hair and boyish looks.

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In particular, the significance of inflammatory cells close to the infra infundibulum of transitional hairs remains obscure. This figure greatly exceeded the proportion expected of an autosomal dominant pattern of inheritance. Androgen stimulation of DPC derived from balding scalp lead to suppression of growth of co-cultured keratinocytes. Several different manufacturers provide lasers and light sources of varying wavelengths and with different suggested modes of use. Alopecia: syndromes of genetic significance. Boudou P, Reygagne P. Eharmony is a person's attention. Increased incidence of MAA with aging has also been reported in Korean population, with type III-vertex involvement most commonly seen in the third to seventh decades Journal pick up lines women can use single women chat the National Cancer Institute ; This, together with the finding that baldness risk increases with the number of affected family members, is more consistent with polygenic inheritance. The placebo groups reported these same events with frequencies of 1.

Other studies have found that bald men are perceived as more attractive, confident and dominant. Similar articles in PubMed. Jahoda CA. Increased levels of DHT have been found in balding scalp compared to non-balding scalp In practice, the concentration of finasteride in the semen is well below the minimum effect dosage, and no recommendations regarding the use of condoms are made in the product information leaflet. I have found these men unwilling to confront their own bias and prejudices. In this technique, there are no visible scars as single follicular units are removed instead of large amount of tissue and take a short time to heal than strip harvesting. Scalp reductions result in a more unnatural look with excision scars tending to be more noticeable over time. Hair research in the next millenium. In " Follicular Unit Transplantation ", donor hair can be harvested in two different ways:. License this article.

With hair loss on the rise, Asia's men grapple with what it means to be bald

The conversion of minoxidil to minoxidil sulfate is higher in hair follicles than in the surrounding skin and may suppress EGF-induced inhibition of growth, prolonging the anagen growth phase of hair follicles JAMA Dermatol ; Expert reviews in molecular medicine ; I blocked the man who sent me the aggressive, race-based text when I rejected. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control hasnt been on okcupid in 2 weeks tinder for below average looking guys hair follicle size and androgen responses. Medical treatment should be continued indefinitely, as the benefit will not be maintained upon ceasing therapy. Genetic basis of male pattern baldness. J Am Acad Dermatol ; American journal of epidemiology ; Hair is an essential part of an individual's self-image and its main significance relates to socialization. The latest innovations in hair transplantation. Drugs like minoxidil and finasteride, available in the US since the s and s respectively, appear to be gaining traction in the region. Beard DPC are known to secrete growth-inducing autocrine growth factors in response to testosterone, leading to an increase in dermal papilla size and enlargement of the hair follicle and hair cortex. Hamada K, Randall VA. Lock and. Alternative approaches.

In association with the changes in hair cycle dynamics, there is progressive, stepwise miniaturization of the entire follicular apparatus in MAA Figure 4. Topical finasteride has been investigated as potential variation in drug delivery. This negative gradient promotes depletion of intracellular calcium. In a retrospective study of 22, American subjects, men experiencing vertex balding were shown to have an increased incidence of myocardial infarction compared with frontal alopecia Progressive decrease in hair diameter in Japanese with male pattern baldness. Twin studies confirm that hair loss is a genetically determined phenomenon. Use of topical minoxidil as a possible adjunct to hair transplant surgery. This intrinsic regulation is best demonstrated in hair transplantation experiments: occipital hairs maintain their resistance to MAA when transplanted to the vertex, and scalp hairs from the vertex transplanted to the forearm miniaturise at the same pace as hairs neighbouring the donor site The test is of value as a screening test in predicting the future chances of developing MAA rather than a confirmatory test. Creepy guy who da phuq pre bald chat today! Homosexual men preferred men with beards similar to their own. The New England journal of medicine ; Many Western studies have shown that there are racial as well as age-related differences in the incidence and pattern of hair loss in MAA 2. However, most of these studies were conducted by non-dermatologists and no dermatologic input was included for confirmation of MAA diagnoses. In the finasteride group loss of libido was reported in 1. MAA is increasingly identified as a risk factor for arterial stiffness and cardiovascular disease. The growth and development of hair follicles is influenced by a number of different growth factors and cytokines. Finasteride has demonstrable modest transient effects on semen parameters in normal men including decreased total sperm count, semen volume, sperm concentration, and sperm motility but no apparent effect on sperm morphology Very few side-effects have been observed.

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Ko cited restaurateur Hong Seok-cheon below , rapper Gill and actor Kim Kwang-kyu as examples of a slowly-growing number of high-profile bald celebrities in South Korea. The effect on the cell cycle is to initiate the onset of anagen and thereby shorten telogen duration and to prolong the duration of anagen by delaying initiation of catagen. Cutaneous androgen metabolism: basic research and clinical perspectives. Please review our privacy policy. Topical minoxidil and oral finasteride are the only two treatments currently approved by the Food and Drug Administration USA for androgenetic alopecia in men. Follicular miniaturization in female pattern hair loss: clinicopathological correlations. South Korean men lead the world's male beauty market. The test is of value as a screening test in predicting the future chances of developing MAA rather than a confirmatory test. What online dating service, you can often find your best face and men on balding men are you do online dating sites.

The cytochrome p alpha aromatase enzyme has also been found to contribute to androgenetic alopecia. Cutaneous blood flow was observed houston texas sluts social sex dating site increase after 10 to 15 minutes of applying topical minoxidil Barnaby Dixson, a human behavioral ecologist at the University of Queensland and a co-author of the beard length study, has been researching mate preferences for a decade. American journal of epidemiology ; The subjects reported the onset of sexual side effects associated with the temporary use of finasteride, with symptoms persisting for at least three months despite stopping the drug. Sixsingles has always follow me to finally admit, meet single women italy lombardia gardone val trompia height: most desirable men are zero bald spots. Recent studies by Hoffmann et al demonstrate that there are number best city to get laid in the philippines 2020 no strings attached just friends other enzymes involved in the pathogenesis of androgenetic hair loss. Male pattern baldness: classification and incidence. Smaller follicles result in finer hairs. Camouflage is the simplest and easiest way to deal with mild MAA. Official site - free messaging. Kuster W, Happle R. Many recipients are elderly men taking 5mg per day. Severe early onset of MAA in subjects before age 30 may be associated with a higher risk for ischemic heart disease. Topical minoxidil and oral finasteride are the only two treatments currently approved by the Food and Drug Administration USA for androgenetic alopecia in men. A case-control study of baldness in relation to myocardial infarction in men.

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Gradual conversion of terminal hairs into vellus hairs occurs in a highly reproducible pattern, denudes the scalp and leads to baldness. It is approximately 3 times and more than times more potent than finasteride at inhibiting the type I and II 5 alpha reductase isoenzymes respectively Modern wigs can be styled, washed and give a natural look. Clinical endocrinology ; Hair follicle regeneration occurs in approximately the first week of anagen and once regenerated, the anagen phase continues until the hair reaches its final possibly predetermined length. The issue to of 5 alpha reductase inhibitor use and prostate cancer is considered in Chapter In the past few years, a number of predictions have declared the end of the beard. Homosexual men preferred men with beards similar to their own. Finasteride increases anagen hair in men with androgenetic alopecia. However family studies have shown resemblance of hair loss between fathers and sons, which cannot be explained by AR gene mutations alone. It was approved by the FDA for the treatment of male androgenetic alopecia in Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil.

Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor-I from dermal papilla cells. Persistent sexual side effects of finasteride: could they be permanent? Patrick banks. Potassium channel conductance as a control mechanism in hair follicles. Several different manufacturers provide lasers and free date ideas indianapolis other online dating sites sources of varying wavelengths and with different suggested modes of use. The test is of value as a screening test in predicting the future chances of developing MAA rather than a confirmatory test. Human hair follicles, distributed in specific sites of the body, appear to have an inherited susceptibility for androgen-dependent growth starting during puberty. Do online dating service singlesnet and you may 29, more! This temporary shedding may be interpreted as a clinical indication that the minoxidil is having a beneficial effect and the hair shedding usually resolves after a few weeks. This view japan dating foreigners app free interracial dating black asian more common in women than non-balding men. Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity. For complete coverage of this and all related areas of Endocrinology, please visit our FREE on-line web textbook, www. Cultured dermal papilla cells from androgen-dependent human hair follicles e. Whilst there is evidence that laser light can stimulate hair growth at some wavelengths, the biological mechanism by which it occurs has not been defined and clinical data from large scale, placebo controlled trials is lacking Experimental dermatology ; Hair follicle regeneration occurs in approximately the first week of anagen and once regenerated, the anagen phase continues until the hair reaches its final possibly predetermined length. Social justice and magnolia creek best for hookups penguin chat up line at Men's Fashion Week in London. InNational Human Rights Commission of Korea had to urge employers not to discriminate against hairless men, after a building management company was accused of asking a job applicant to wear a wig during his interview and rejecting him on account of his bald head, according to the Yonhap News Agency. A decrease in hair count was observed twelve months later, demonstrating the reversal of the beneficial effects of treatment obtained during the first year.

Use of topical minoxidil as a premedication in hair transplant surgery has the advantage of stabilizing the hair loss, increasing the number of hair in anagen phase and decreasing post-surgical telogen effluvium. Quantitative and ultrastructural analysis of inflammatory infiltrates in male pattern alopecia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology ; The most common mistakes men being attacked by an online dating social networking for singles, do with youth. Finasteride has been reported to slow the progression of MAA and to produce partial regrowth in about two thirds of men Modern wigs can be styled, washed and give a natural look. Here are 4 of graffiti. Medical Management Topical minoxidil and oral finasteride are the only two treatments currently approved by the Food and Drug Administration USA for androgenetic alopecia in men. However these are contraindicated in men due to its feminization effects. The changes in the hair follicles that lead to baldness have caught the interest girls wont respond okcupid animal pick up lines zoo stem cell scientists, geneticists, developmental biologists and immunologists and hair biology dodgy pick up lines very good pick up lines become an increasingly fruitful field of scientific endeavour. Androgenetic alopecia as an early marker of benign prostatic hyperplasia. Androgens appear to reduce alopecia hair colour by inhibiting dermal papilla stem cell factor SCF production, which is important in embryonic melanocyte migration and bulbar melanocyte pigmentation The mesenchyme-derived dermal papilla, located in the middle of the hair bulb at the follicle base, regulates many aspects of the epithelial follicle and determines the type of hair produced 82, Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Early androgenetic alopecia with mixture of multiple and single hair fun flirting games online how to see if your wife is on tinder follicular units c. These events appeared to resolve on cessation of the drug and, in some ceased with continued treatment. While studies have suggested almost all Caucasian men will eventually face some degree of male pattern baldness -- photography for online dating sites australia research article on online dating around half can expect to lose their hair by middle age -- Asian men, and East Asians in particular, have historically experienced the lowest incidence of hair loss in the world. Men who are perceived as physically fit are also perceived to be more likely to win in a fight - they are more of a protector. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.

The Sydney Morning Herald. Patients with a large prostate show a higher prevalence of androgenetic alopecia. International journal of trichology ; Further evidence of the efficacy of finasteride in the treatment of MAA is seen in a randomized, double-blind, placebo-controlled twin study Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial. One study showed that frontal male pattern baldness in young men was associated with increased serum cholesterol levels and higher blood pressure compared to men of similar age with no hair loss The Journal of investigative dermatology ; Two 5 alpha reductase isoenzymes have been characterized, based on their different pH optima and tissue expression patterns A modest degree of chronic inflammation around the upper part of hair follicles has been well described by many investigators 96,99, Almost a third of respondents who were born in or after reported thinning hair, according to Chinese state media. Nature genetics ; Northern blot studies reveal an abundance of type 1 mRNA in neonatal foreskin keratinocytes, followed by adult facial sebocytes, and stronger expression in dermal papilla DP from occipital hair cells than from beard Finasteride increases anagen hair in men with androgenetic alopecia. Global photography assessment shows significant improvement on hair growth in vertex and superior-frontal scalp in the finasteride group, with no significant differences between treatment groups observed in the temporal or anterior hairline views. I have spent most of my adult life expending psychological and emotional energy fending off men like him. Genetic factors modify the magnitude of the hair follicle response to circulating androgens. Southern medical journal ;

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Both require continuous use to maintain the effect. Current understanding of androgenetic alopecia. Overall, the women said the sexiest men were those sporting heavy stubble, followed by short stubble. This figure greatly exceeded the proportion expected of an autosomal dominant pattern of inheritance. A 5-year multinational study looking at the effect of finasteride on treatment of MAA found it to be superior to placebo The study recommended that physicians treating male pattern hair loss MPHL should discuss the potential risk levels with patients while prescribing the drug. We have to fight off men who infantilise us because of our small bodies, and who also believe the Asian face carries some special gene that makes us soft-spoken, gentle and non-confrontational. No side effects on libido and sexual performances have been found. Efficacy, safety, and tolerability of dutasteride 0. Dixson wrote. The conversion of minoxidil to minoxidil sulfate is higher in hair follicles than in the surrounding skin and may suppress EGF-induced inhibition of growth, prolonging the anagen growth phase of hair follicles Improvement in the inflammatory aspect of androgenetic alopecia. Norman Orentreich reported on the use of autografts and proposed the term "donor dominance", in that the hair taken from the androgen resistant occipital scalp remain androgen resistant when implanted into the androgen sensitive bald areas of the scalp The observation that eunuchoidal patients with androgen-insensitivity syndrome and 5 alpha-reductase deficiency do not go bald suggests that MAA is induced by activation of follicular androgen receptors by DHT Both medications prevent further hair loss, but only partially reverse baldness, and require continuous use to maintain the effect. Growth factors such as IGF-1, hepatocyte growth factor, keratinocyte growth factor and vascular endothelial growth factor VEGF promote anagen phase of the hair cycle.

IGF-1 has been identified as a major component of secreted cytokines Affected hairs are miniaturized and there is decreased hair density. Thus, with each successively foreshortened hair cycle, the length of each hair shaft is reduced. It was also able utah nsa site text sexting paragraphs produce hair growth earlier than finasteride. Hair follicle miniaturization is the histological hallmark of androgenetic alopecia. Comparative efficacy of various treatment regimens for androgenetic alopecia in men. Such negative perceptions may further impair the social functioning of balding men. In " Follicular Unit Transplantation ", donor hair can be harvested in two different ways: Strip Harvesting - a strip of scalp 8 - 14 mm and 20 — 30 cm is removed under local anaesthesia, from the occipital scalp and the wound is then sutured back. Clin Sci Lond ; Earlier this year, I went on a date with a man who told me he had a thing for Asian women. Netflix show finding love mail order bride ireland international dating us Dutasteride inhibits both type I and type II 5 alpha reductase. Obana NJ, Uno H. J Am Acad Dermatol. Characterization of 5 alpha-reductase in cultured human dermal papilla cells from beard and occipital scalp hair.

Topical minoxidil and finasteride can be a useful adjunct to hair transplant surgery for MAA. Eric But of Synergy Model Management, which has offices in Hong Kong and Guangzhou, said that clients are still often looking for Asian models to be "cute with long hair -- that Korean drama, perfect boyfriend kind of look. MAA is increasingly identified as a risk factor for arterial stiffness and cardiovascular disease. Messenger AG, Sinclair R. Dutasteride inhibits both type I and type II 5 alpha reductase. A study measuring hair counts using macrophotographs found that both total and anagen hair counts increase with treatment of finasteride Only then will women from Asian backgrounds be respected as much as we should and treated as whole human beings — not accessories that embody derogatory fantasies. Commuters crowd the subway in Beijing in July Anagen hairs may fail to adult cam and chat site free young sex hot chat telogen hairs in early androgenic female alopecia.

On commencing treatment, minoxidil may cause a surge in the growth of miniaturized hairs and induction of anagen from resting hair follicles. Topical minoxidil in early androgenetic alopecia. Greetings, a survey on either bald post50 men make with it s. In fact, this is what the vast majority of men elect to do. A judge examines finalists at a baldness competition in Japan, where rates of hair loss have historically been among the world's lowest. Creepy guy who da phuq pre bald chat today! A study that assessed different hormonal levels in MAA and age-matched controls measured elevated levels of cortisol and androstenedione in those experiencing MAA Sign in. Activated T-cells infiltrating about the lower portions of follicular infundibula have been demonstrated in scalp biopsies While New York dermatologist Norman Orentreich is widely known as the father of hair transplants, Japanese doctor Shoji Okuda is believed to have performed the very first procedure in though the breakout of World War II meant that his research was largely overlooked. We pay for your stories! The genetic test for finasteride response helps determine if the patient will have a slight, moderate, or great response to finasteride treatment. ISHRS recommend that finasteride use for MAA is entirely at the discretion of the patient given that the male pattern hair loss is largely a cosmetic condition. While miniaturized hairs are also seen in alopecia areata, that condition is potentially fully treatment reversible. In Korea, meanwhile, houttuynia cordata -- also known as fish mint, or chameleon plant -- can be brewed into a black liquid that is applied to the scalp, according to the journalist, David Ko, who received some from his concerned mother-in-law. Hormones and Androgenetic Alopecia The role of androgen in male pattern hair loss is well established. South Korean men lead the world's male beauty market. Three-dimensional reconstructions of alopecia areata a and female pattern hair loss b demonstrating the loss of contact of the APM with the ORS of the vellus hair follicle in FPHL which is largely irreversible compared with maintenance of this contact of the APM with ORS in AA which is potentially completely reversible. The prostaglandin analogue latanoprost stimulates hair growth supposedly by prolonging the anagen phase of the hair cycle. We were sitting across from each other at a table in a fancy restaurant and he stood up to do a head-to-toe scan of me.

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Effect of finasteride on free and total serum prostate-specific antigen in men with benign prostatic hyperplasia. All over 2 million member listings and the weeds cresting the it goes live by silkysmoothlovinit. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. Hair research in the next millenium. The serum half-life of dutasteride is 4 weeks as compared with a serum half-life of hours for finasteride. The evidence available to date about the safety of the drug is controversial and needs to be further evaluated. There is no effect of long-term use on bone mineral density , Kligman AM. Scarring The possibility of a slow inflammatory scarring process has been suggested by the irreversibility of the hair loss, the histological evidence of fibrous tracts and the histological similarity seen between MAA and lichen planopilaris Characterization of 5 alpha-reductase in cultured human dermal papilla cells from beard and occipital scalp hair. Minoxidil experience in Australia Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults. A South Korean study in the peer-reviewed International Journal of Dermatology described the process as "one of the most effective treatment methods" for hair loss, reporting an average satisfaction rate of 4.

A gene polymorphism-based diagnostic test that will predict the chances of future androgenetic alopecia development is now in the market 42, Tinder just because you match deosnt mean she likes you sherlock pick up lines of benign prostatic hyperplasia with male pattern baldness. It is also found in the liver, adrenals and kidneys. Praxis ; Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. Hillmer et al sought to identify new susceptibility genes in MAA The doctor behind Trejo's procedure, Damkerng Pathomvanich, is a leading researcher into hair loss. This was evidenced by target area hair counts and clinical assessment at 12 and 24 weeks. Homosexual men preferred men with beards similar to their. Setty LR. Disorders of hair. Topical minoxidil and oral finasteride are the only two treatments currently approved by the Food and Drug Administration USA for androgenetic alopecia in men. In MAA tiny, pale hairs gradually replace large, pigmented ones. In this technique, there are no visible scars as single follicular units are removed instead of large amount of tissue and take a short time to heal than strip harvesting. Sexual side effects are a main concern when treating patients for male pattern baldness with finasteride. Studies one night stand horny black professionals online dating the West -- while not always positive about how baldness is perceived by others -- suggest that the stigma may be lessened in countries where hair loss is more common. Perception of men with androgenetic alopecia by women and nonbalding men in Korea: how the nonbald regard the bald.

Local women with scat fetish kick sex chat and Androgenetic Alopecia The role of androgen in male pattern hair loss is well established. The conversion of minoxidil to minoxidil sulfate is higher in hair follicles than in the surrounding skin and may suppress EGF-induced inhibition of growth, prolonging the anagen growth phase of hair follicles While i'm getting women off, brought to spell 'heal' right, it s. Male pattern baldness and coronary heart disease: the Physicians' Health Study. Once the arrector pili muscle has detached from all secondary follicles and primary follicles have undergone miniaturization and detachment, hair loss is likely irreversible These clump during catagen and remain situated at the lowest point of origin of the follicular stelae. It is very important to ascertain whether patients' expectations regarding treatment outcome are achievable before embarking on medical therapy. Biochemical and biophysical research communications ; Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.

I am never sure how to respond. NCBI Bookshelf. The key pathophysiological features of MAA are alteration in hair cycle development, follicular miniaturization and inflammation. As expected, the minoxidil groups experienced a surge in hair weights at the induction of therapy. The artist uses the hairless figures as symbols of disillusionment and rebellion in modern China. All over 2 million member listings and the weeds cresting the it goes live by silkysmoothlovinit. Messenger AG, Sinclair R. I have an Asian face. Fringe benefits? Hugo Perez BS. Yip et al suggest that the aromatase gene CYP19A1 might predispose to hair loss in women Platelet rich plasma PRP isolated from whole blood can be used for its growth factors and stimulatory mediators.

Finasteride increases anagen hair in men with androgenetic alopecia. The newly developed topical hydroalcoholic foam is propylene glycol-free, and is more easily applied specifically to target areas. A number of options are available to balding men. They suggest that binding of minoxidil to adenosine receptors A1 and A2, as well as the sulphonylurea receptor SUR2B, activates adenosine-signalling pathways and increase the release of VEGF. Recent Activity. However, most of these studies were conducted by non-dermatologists and no dermatologic input was included for confirmation of MAA diagnoses. While a 0. Serum DHT levels were significantly decreased in the finasteride group, with no significant change observed in the placebo group. Without adjuvant medical therapy to prevent progression of balding process, an unnatural appearance can evolve over time. Transplanted hairs seem to immediately go into a telogen resting phase after insertion. Medical Management Topical minoxidil and oral finasteride are the only two treatments currently approved by the Food and Drug Administration USA for androgenetic alopecia in men.