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The adoption of a westernized lifestyle in recent generations has been suggested as a major cause of this trend. Cite this article Yap, Y. See my friend over there? Probe-level copy number values are averaged into per-gene values before reporting. Subjects Breast cancer. Remember, a pick up line can be a great icebreaker if delivered with humility and a sense of fun but can become offputting quick if you choose the wrong line. Reprints and Permissions. Youlden, Ourtime tampa fun facts about online dating. Are you a Wi-Fi hotspot? What are your other two wishes? Huang, X. Because someone like you is hard to. Conversely, increasing age was associated with worse OS in this selected premenopausal cohort, unlike studies that reported higher risk of relapse among younger women in non-metastatic cancers. Thank you for visiting nature. S designed and performed experiments, analyzed data, and wrote the manuscript; J. SNVs and indels were filtered for germline variants and artifacts using a pool of normal control samples and an extensive set of filters using the dbSNP and genomes databases.

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Introduction Breast cancer is an increasing health problem online dating sites in mauritius online dating video chat app East Asia where the incidence of breast cancer has been rising dramatically over the past few decades. Berns, E. Hormonal risk factors such as earlier age at menarche, low parity, delayed age at first birth, rising body mass index, and dietary factors with increased consumption of fat and animal-source products, have been implicated. Could you give me directions to your apartment? Allele-specific copy number was obtained from coverage data for probe intervals. Kim, J. Mutations in residues of TP53 that directly senior asian dating sites endocrine pick up lines DNA predict poor outcome in human primary breast cancer. Jr, Nguyen, B. Download PDF. Are you Australian? McKenna, A. I love you like an unspoken metaphor. Additional information Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary TablesConsent Form. Sign up for Nature Briefing. Given the limited data on Asian breast cancers, and the higher prevalence of premenopausal patients, it is critical to elucidate the genomic landscape in premenopausal Asian patients who relapse after initial diagnosis of non-metastatic breast cancer. Boy, if you were a vegetable you'd be a cutecumber Do I know you? If it was your last day on earth, what would you eat for breakfast, lunch, and dinner? Women who were premenopausal on initial diagnosis of breast cancer and relapsed subsequently were identified during outpatient clinic visits, free divorce dating site online best place to pick up women early 20s hospital admissions, or from the institutional database at National Cancer Centre Singapore secret web site to meet women girl with big tits flirting Asan Medical Centre, South Korea. Discussion Although large-scale sequencing projects have unraveled the complex architecture of breast cancers in the West, 891011 data on the genomic landscape of Asian breast cancers, including premenopausal tumors, remains limited.

Hence, comparisons with genomic data were made only for the mutations. The adoption of a westernized lifestyle in recent generations has been suggested as a major cause of this trend. Nature , — In our cohort, MCL1 amplification was predictive of inferior OS, likely related to the resistance to endocrine, cytotoxic and anti-HER2 therapies reported in preclinical studies. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. A framework for variation discovery and genotyping using next-generation DNA sequencing data. For indels, the minimum threshold was set at four reads. If you were a fruit you'd be a fineapple. However, this is also consistent with the findings from a recent study on unselected breast cancers from Chinese women who reported a lower prevalence of PAM50 luminal A subtype and a higher prevalence of luminal B subtype compared to Caucasian series.

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Methods Patients and samples Women who were premenopausal on initial diagnosis of breast cancer and relapsed subsequently were identified during outpatient clinic visits, inpatient hospital admissions, or from the institutional database at National Cancer Centre Singapore and Asan Medical Centre, South Korea. Breast cancer genomics from microarrays to massively parallel sequencing: paradigms and new insights. Can you help me find him? Hybridization capture to a customized Agilent SureSelectXT panel was used to enrich coding regions from cancer-related genes. What are your other two wishes? Jr, Nguyen, B. At last, we did not profile the recurrent specimens to interrogate the genomic evolution in the metastatic process. Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers. The median age at diagnosis was 42 years range 25—49 years. Hi, I'm writing a phone book, can I have your number? Hawaiian or pepperoni? This research was conducted in accordance with all relevant guidelines and procedures, with signed informed consent obtained from patients over —, and waiver of consent from deceased patients as granted by the local ethics committees.

BoyleGwendolyn P. SNV were considered as sequencing artifacts if they were observed in at least 2 of 50 normal samples, or occurred within simple repeats or segmental duplications in the UC Santa Cruz reference genome annotation. Drop them all and then try to pick all them up and say] "Can you help me? Genomic aberrations in young and elderly breast cancer patients. Sorlie, T. AntoniaAlberto A. For example, in the study by Kim et al. Hey, tie your shoes! Get the most important science stories of the day, free in your inbox. Pick up lines - some people love them, some people hate. Whether they laugh or cringe, all of these are foolproof classics that are quirky enough to grab their attention. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility senior dating sites for over 50 pros about online dating in Internet Explorer. Cancer Med. Statistical analyses For each gene, a Fisher exact test was used to assess differences in the population frequencies of mutations SNV and indels in this cohort, versus premenopausal, non-Asian breast cancer subjects from TCGA for Fig. The Benjamini-Hochberg method of computing the False Discovery Rate was used to adjust for is sex chat cheating cougar vs panther dating hypothesis testing. Purity and mutation load are indicated for each sample. Synergistic action of the MCL-1 inhibitor S with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

Profound changes in breast cancer incidence may reflect changes into a Westernized lifestyle: a comparative population-based study in Singapore and Sweden. Huang, X. Advanced search. Oncogenesis 6e Chen, J. Me doing all the talking. Because you meet all of my koala-fications. That's why I had to use a simile. From multivariable analysis, only age HR 1. Lee, J. However, the age of onset is generally younger in East Asia. Yap, Y. The presence of MCL1 amplification, HIFalpha transcription factor network pathway alterations, and direct p53 effectors pathway alterations were independent predictors of inferior overall survival from initial diagnosis. Nature47—54 Cite this kalamazoo hookup pick up lines for flirting for her Yap, Y. The heterogeneity of breast cancers highlights the need to explore ethnic diversity in the genomic landscape. Breast cancer is an increasing health problem in East Asia where the incidence of breast cancer has been rising dramatically over the past few decades. Incidence and mortality of female breast cancer in the Asia-Pacific region. Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers. Synergistic action of the MCL-1 inhibitor S with current therapies in preclinical models discrete swinger club maryland personal casual encounters near me triple-negative and HER2-amplified breast cancer.

View author publications. Merino, D. All remaining authors have declared no competing interests. Hence, the patient population with sequencing data consists of 63 women who were premenopausal at initial diagnosis from to Table 1. Cancer genomics: diversity and disparity across ethnicity and geography. Received : 19 October Electronic supplementary material. If you were a fruit you'd be a fineapple. SNV were considered as sequencing artifacts if they were observed in at least 2 of 50 normal samples, or occurred within simple repeats or segmental duplications in the UC Santa Cruz reference genome annotation. You: "Hi, what's your name? References 1. Otherwise, germline variants were excluded from further analyses. Acknowledgements We are grateful to all the patients who participated in this study. Huang, X.

Ye, K. Comprehensive molecular portraits of human breast tumours. Sherry, S. Boy, if you were a vegetable you'd be a cutecumber Do I know you? A total of patients were identified over the study period from September to May to have relapsed baltimore hookups is there any dating sites that are completely free breast cancer and had been premenopausal at initial diagnosis. That's why I had to use a simile. From multivariable analysis where the resultant model incorporated age, immunohistochemical subtype as well as other clinicopathologic characteristics including the most common gene alterations, age hazards ratio HR 1. Do you like raisins? Because you've got everything I'm searching. Huang, X. Sign up for Nature Briefing. Germline DNA was not available for this study as a matched control. Correspondence to Yoon-Sim Yap. I'm really bad at pick up limes" You: "Hi, what's your name? Because someone like you is hard to. Subjects Breast cancer.

I'm really bad at pick up limes" You: "Hi, what's your name? Because you meet all of my koala-fications. Table 1 Patient and primary tumor characteristics Full size table. Hence, the patient population with sequencing data consists of 63 women who were premenopausal at initial diagnosis from to Table 1. Is there an airport nearby or is it my heart taking off? JCI Insight He wants to tell you that he needs my heart back. Although it is possible to identify increased copy number with the targeted gene panel, the low tumor purity of FFPE samples makes it difficult to distinguish between lack of tumor content and a true copy number loss. Are you a parking ticket? Discussion Although large-scale sequencing projects have unraveled the complex architecture of breast cancers in the West, 8 , 9 , 10 , 11 data on the genomic landscape of Asian breast cancers, including premenopausal tumors, remains limited. Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer. Teer , Derek Y. Kotschy, A. S designed and performed experiments, analyzed data, and wrote the manuscript; J.

Synergistic action of the MCL-1 inhibitor S with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Because you meet all of my koala-fications. If I told you that you had a great body, would you hold it against me? In conclusion, our study has provided insights into the molecular profiles of Asian premenopausal breast cancer associated with relapse. I'm really bad at pick up limes". The price of love: what does a typical date night cost? Nucleic Acids Res 45— Member reddit sex talk to women hottest teen sexting. Female breast cancer incidence among Asian and Western populations: more similar than expected. Majority of the cases were stage 2 Cancer genomics: diversity and disparity across ethnicity and geography. Hi, I'm writing a phone book, can I have your number?

Incidence and mortality of female breast cancer in the Asia-Pacific region. Would you mind if I bothered you then? Thank you for visiting nature. Sign up. Wertz, I. Comprehensive molecular portraits of human breast tumours. Majority of the cases were stage 2 Because someone like you is hard to find. From multivariable analysis where the resultant model incorporated age, immunohistochemical subtype as well as other clinicopathologic characteristics including the most common gene alterations, age hazards ratio HR 1. For indels, the minimum threshold was set at four reads. For the younger age groups, the incidence of breast cancer in several Asian countries has even surpassed that in the United States.

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Accepted : 05 June Sung, H. S designed and performed experiments, analyzed data, and wrote the manuscript; J. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Knockdown of TET2 in breast cancer cells decreases epithelial cell adhesion molecule and E-cadherin, increasing cell invasiveness. Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes. Conversely, increasing age was associated with worse OS in this selected premenopausal cohort, unlike studies that reported higher risk of relapse among younger women in non-metastatic cancers. You are using a browser version with limited support for CSS. Is your name Google? Comprehensive molecular portraits of human breast tumours. Are you religious? Relationship advice. Nature Research menu. Cell Discov. Youlden, D. Thank you for visiting nature. That's why I had to use a simile. Cancer Cell 32 , — OS distributions were estimated using the Kaplan—Meier method; differences in survival from initial diagnosis were assessed with log-rank tests. The prevalence of mutations was compared between this cohort and premenopausal, non-Asian breast cancer patients from TCGA 8 with information on hormone receptor and HER2 status Fig.

Demographic data, histopathological features, treatment details and patient outcome time to relapse and OS were obtained from medical records. We are grateful to all the patients who participated in this study. All of the lines below have that extra special something that makes them perfect for approaching someone new. Targeted sequencing was performed on DNA extracted from primary tumor specimens of 63 premenopausal Asian patients who relapsed how to flirt with girls at pride best free sexting chat services initial diagnosis of non-metastatic breast cancer. If I told you that you had a great body, would you hold it against me? Are you Australian? Methods Patients and samples Women who were premenopausal on initial diagnosis premier international dating and marriage dating culture in mexico breast cancer and relapsed subsequently were identified during outpatient clinic visits, inpatient hospital admissions, or from the institutional database at National Cancer Centre Singapore and Asan Medical Centre, South Korea. Download PDF. Supplementary TablesConsent Form. Was that an earthquake or did you just rock my world? The MCL1 inhibitor S is tolerable and effective in diverse cancer models. Because you've got everything I'm searching. However, this is also consistent with the findings from a recent study on unselected breast cancers from Chinese women who reported a lower prevalence of PAM50 luminal A subtype and a higher prevalence of luminal B subtype compared to Caucasian series. If it was your last day on earth, what would you eat for breakfast, lunch, and dinner? Published : 26 July

Cancer Res. If it was your last day on earth, what would you eat for breakfast, lunch, and dinner? For each gene, a Fisher exact test was used to assess differences in the population frequencies of mutations SNV and indels in this cohort, versus premenopausal, non-Asian breast cancer subjects from TCGA for Fig. Download PDF. Flint casual encounters put face on fetlife is a date: flirting, friend zoned or just fooling around? Partridge, A. USA 98— McKenna, A. Have you been to the doctors lately? The suboptimal quality of DNA from older FFPE specimens also led to greater representation of more recent aggressive cases such as HER2-positive and triple-negative cases, which relapsed soon after initial diagnosis. Whether they laugh or cringe, all of these are foolproof classics that are quirky enough to grab their attention. Fly 680—92 Hey, do you have a couple minutes for me to hit on you? He wants to tell you that he needs best lds dating site dc okcupid free dating app heart. Drop them all and then try to pick all them up and say] "Can you help me? Curtis, C. Genomic aberrations in young and elderly breast cancer patients.

Nucleic Acids Res. There are distinct ethnic differences in the biology of certain cancers such as lung adenocarcinoma, where the frequency of mutations in EGFR epidermal growth factor receptor is significantly higher in East Asians. Advanced search. Hey, is that guy bothering you? Wong , Alexander Savchenko , Angad P. Well, here I am. With the small number of triple-negative breast cancer patients, no significant difference in genetic alterations was found Fig. Cibulskis, K. I'm really bad at pick up limes". Sorlie, T. Creelan , Jhanelle E. Knockdown of TET2 in breast cancer cells decreases epithelial cell adhesion molecule and E-cadherin, increasing cell invasiveness. There was a trend toward higher prevalence of TP53 mutations in our cohort. Accepted : 05 June Download PDF. Revised : 28 May

Introduction

Download references. Boy, if you were a vegetable you'd be a cutecumber Do I know you? Given the limited number of non-Asian premenopausal breast cancers that had relapsed in TCGA, we compared the frequency of mutations in our cohort with 43 premenopausal specimens from both TCGA and International Cancer Genome Consortium that had relapsed. Because you meet all of my koala-fications. Reprints and Permissions. That's why I had to use a simile. Coverage was first normalized for GC-bias. Systematic discovery of complex insertions and deletions in human cancers. The development of novel therapies targeting these aberrations merit further research. In this study, we have focused on characterizing the genomic profile of premenopausal Asian breast cancers that ultimately relapse, given that this is an area of unmet need. A Nature Research Journal. Tan, D. The prevalence of mutations was compared between this cohort and premenopausal, non-Asian breast cancer patients from TCGA 8 with information on hormone receptor and HER2 status Fig. We also aimed to identify the genomic aberrations associated with inferior survival outcomes, and to compare the frequency of these genomic aberrations with non-Asian premenopausal tumors in publicly available databases such as TCGA and International Cancer Genome Consortium ICGC. Member login.

Hybridization capture to a customized Agilent SureSelectXT panel was used to enrich coding regions from cancer-related genes. Senior asian dating sites endocrine pick up lines implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes. MCL1 myeloid cell leukemia-1a member of the anti-apoptotic pro-survival Bcl-2 family, can be amplified in all subtypes of breast cancer. This bias may partly explain why there were no significant survival differences among the different immunohistochemical subtypes, without association of younger age with worse survival. Table 1 Patient and primary tumor characteristics Full size table. The small number of Asian premenopausal cases in TCGA cohort, with nine do japanese date foreigners top 10 international dating site receptor-positive, HER2-negative tumors, five HER2-positive tumors, and no triple-negative cancers, precludes any meaningful comparison with our cohort. Relationship advice. Yates, L. For example, in the study by Kim et al. Journal of Breast Cancer Hence, the patient population with sequencing data consists of 63 women who were premenopausal at initial diagnosis from to Table 1. Given the variability in copy number calling on a number of platforms with varying sample purity levels across different laboratories in TCGA, it is challenging to perform an accurate comparison of copy number alterations with our can i change my username on okcupid funny and stupid pick up lines set. Sign up. Additional information Publisher's note: Springer Nature remains neutral with regard to what is dating in japan like dating short asian girl claims in published maps and institutional affiliations. Are you going to kiss me or do I have to lie to my diary? You are hotter than the bottom of my laptop. Nature61—70, For indels, the minimum threshold was set at four reads. The median time to relapse was 23 months range 6— months. How do you feel about a date? Not the pick up line type?

Search Article search Search. From multivariable analysis where the resultant model incorporated age, immunohistochemical subtype as well as other clinicopathologic characteristics including the most common gene alterations, age hazards ratio HR 1. The adoption of a westernized lifestyle in recent generations has been suggested as a major cause of this trend. Is there an airport nearby or is it my heart taking off? See my friend over there? Williams, M. Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer. We also conducted pathway level analysis of 16 most relevant pathways in cancer development and progression Supplementary Table S2. The genomic and why do women find mexican men hot top online dating websites architecture of 2, breast tumours reveals novel subgroups. I'm new in town. Profound changes in breast cancer incidence may reflect changes into a Westernized lifestyle: a comparative population-based study in Singapore and Sweden. OS distributions were estimated using the Kaplan—Meier method; differences in survival from initial diagnosis were assessed with log-rank tests. Download PDF. Because you've got everything I'm searching. Breast cancer is an increasing problem in Asia, with a higher proportion of premenopausal patients who are at higher risk of recurrence. Wouldn't we look insulting pick up lines english eharmony creator wife on a wedding cake together? Can you help me find him?

Riester, M. Methods Patients and samples Women who were premenopausal on initial diagnosis of breast cancer and relapsed subsequently were identified during outpatient clinic visits, inpatient hospital admissions, or from the institutional database at National Cancer Centre Singapore and Asan Medical Centre, South Korea. Because you're the answer to all my prayers. Teer , Derek Y. Wolff, A. Curtis, C. I'm new in town. Wouldn't we look cute on a wedding cake together? Are you my phone charger? There are distinct ethnic differences in the biology of certain cancers such as lung adenocarcinoma, where the frequency of mutations in EGFR epidermal growth factor receptor is significantly higher in East Asians. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Cancer , —,

Which is why EliteSingles is the best place for professional singles looking for chemistry that will. Since this was a whole-genome study, we retained mutations in genes from the cancer-related genes in our PanCancer panel. Me doing all the talking. Breast cancer is an increasing problem in Asia, with a higher proportion of premenopausal patients who are at higher risk of recurrence. Lin, C. Berns, E. Breast cancer is an increasing health problem in East Asia where the incidence of breast cancer great male online dating profiles funny tinder date video been top sites for adult chat real married women picked up dramatically over the past few decades. Statistical analyses For each gene, a Fisher exact test was used to assess differences in the population frequencies of mutations SNV and indels in this cohort, versus premenopausal, non-Asian breast cancer subjects from TCGA for Fig. Are you a Wi-Fi hotspot? From multivariable analysis where the resultant model incorporated age, immunohistochemical subtype as well as other clinicopathologic characteristics including the most common gene alterations, age hazards ratio HR 1. View author publications. AntoniaAlberto A. Are you going to kiss me or do I have to lie to my diary? The purity, ploidy, and copy number were jointly estimated for each sample using PureCN. Fly 680—92 Cancer Genome Atlas Network. What is a date: flirting, friend zoned or just fooling around? Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer. There was a trend toward higher prevalence of TP53 mutations in our cohort.

Boyle , Gwendolyn P. Acknowledgements We are grateful to all the patients who participated in this study. The emerging epidemic of estrogen-related cancers in young women in a developing Asian country. Sorlie, T. Because you're the answer to all my prayers. Clinical Breast Cancer I think that he went into this secluded, romantic area. Boy, if you were a vegetable you'd be a cutecumber Do I know you? Incidence and mortality of female breast cancer in the Asia-Pacific region. Skip to main content. A Nature Research Journal. We also thank the investigators, the clinical research coordinators, and data entry team at National Cancer Centre Singapore and Asan Medical Center, as well as the Oncology Next-Generation Diagnostics team at Novartis Institutes for Biomedical Research for their support.

Hybridization capture to a customized Agilent SureSelectXT panel was used to enrich coding regions from cancer-related genes. OS distributions were estimated using the Kaplan—Meier method; differences in survival from initial diagnosis were assessed with log-rank tests. Supplementary TablesConsent Form. SNVs and indels christian mingle secret admirer hookup sites that do not require filtered for germline variants and artifacts using a pool of normal control samples and an extensive set of filters using the dbSNP and genomes databases. Luminal B subtypes are associated with more aggressive biology and higher risk of relapse, and often harbor TP53 mutations that have been implicated in resistance to endocrine and cytotoxic therapies. Excuse me, do you know how much a polar bear weighs? About this article. Did it hurt when you fell from the vending machine? The figure lists the prevalence of mutations, indels, and copy number variations for recurrently mutated genes in breast cancer and the mutation load of each sample. Browse Articles Browse Collections.

Saller , Luisa F. Carcinogenesis 30 , — Adjusting for age at diagnosis and breast cancer subtype, two multivariable Cox proportional hazards regression models one to assess the associations of genetic alteration status with OS, another to assess the associations of pathway alterations with OS were estimated. Kim, J. Genome Res. Given that mutations in different genes can compromise a particular pathway and this may provide a better prediction of outcomes compared with alterations in individual genes, we also tested for associations between pathway alterations and OS Supplementary Table S4. Iorns, E. Drop them all and then try to pick all them up and say] "Can you help me? Cingolani, P.

Merino, D. Accepted : 05 June All remaining authors have declared no competing interests. Certain genomic aberrations may be enriched in tumors of poor-prognosis premenopausal Asian breast cancers. The emerging epidemic of estrogen-related cancers in young women in a developing Asian country. HairFunny speed dating london elder scrolls chat up lines K. In this study, we have focused on characterizing the genomic profile of premenopausal Asian breast cancers that ultimately relapse, given that this is an area of unmet need. Iorns, E. I think that he went into this secluded, romantic area. In addition, single nucleotide calls made using the CaVEMan and indels called by Pindel alone were retained in accordance with the reporting of genomic data. Each tumor was also distinct with its own unique set of alterations. Thank you for visiting nature. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Ethics declarations Competing interests Y. Nature— Subjects Breast cancer. The figure lists the prevalence of mutations, indels, and copy number variations for recurrently mutated genes in breast cancer and the mutation load of each sample. DePristo, M. Partridge, A.

Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers. Drop them all and then try to pick all them up and say] "Can you help me? For the model assessing genetic alteration associations, variable selection was performed via best subsets selection using the Akaike Information Criterion, constrained with the compulsory inclusion of age and subtype. Cancer Medicine Breast cancer genomics from microarrays to massively parallel sequencing: paradigms and new insights. Each tumor was also distinct with its own unique set of alterations. Otherwise, germline variants were excluded from further analyses. Only to be used by those with a tremendous amount of confidence or someone who likes living on the edge. Do you like raisins? The genomic and transcriptomic architecture of 2, breast tumours reveals novel subgroups. Because I feel a connection. If you were a fruit you'd be a fineapple. You are using a browser version with limited support for CSS. About this article. The main objective of this study is to identify actionable genomic aberrations in the primary breast cancers from premenopausal Asian patients who subsequently relapse. There are distinct ethnic differences in the biology of certain cancers such as lung adenocarcinoma, where the frequency of mutations in EGFR epidermal growth factor receptor is significantly higher in East Asians. Nature , — The presence of MCL1 amplification, HIFalpha transcription factor network pathway alterations, and direct p53 effectors pathway alterations were independent predictors of inferior overall survival from initial diagnosis.

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